Allosteric Regulation of the Human Proteasome

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Image: Prepared from PDB 5m32.

The proteasome is a large biomolecular complex responsible for protein degradation. Recent experimental data revealed that there is an allosteric communication between a core and regulatory parts of the proteasome. In the project, researchers have used atomistic simulations to study molecular details of the allosteric signal – in their study triggered by a covalent inhibitor. While the inhibitor causes only subtle structural changes, the proteasome-wide fluctuation changes may explain the self-regulation of the biomolecular machine.

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Principal Investigator

Michal H. Kolář

Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry